Influence Of Glass Material Of Ampoule On Quality Of Injection

The packaging process of injections needs to be sterilized at high temperature, and the injections have to be stored for a long time. Because the ampoules containing the injections are in direct contact with different types of liquid medicines, the two will affect each other, resulting in changes in the pH value of the injections, and the liquid medicine. Precipitation, discoloration, flakes, etc. can affect the quality of injections. Therefore, it is necessary to understand the composition, type and properties of ampoule glass materials in order to use them correctly.

The main component of glass is silicon dioxide, which is brittle in texture. And the melting temperature is high, which cannot directly meet the basic requirements of ampoule production. Therefore, we often add oxides of sodium, potassium, calcium, magnesium, aluminum, iron, boron and other elements to the basic skeleton of the glass to change its physical and chemical properties. At present, the low-borosilicate glass ampoules commonly used in China have adapted to a certain extent in my country's national conditions of backward production equipment and technology, low cost, and high demand, but the wide application of such glass products has also hindered the development of pharmaceutical glass in my country. Objectively speaking, low borosilicate glass is a transitional property of neutral borosilicate glass that lowers the quality grade and various performance indicators. Therefore, low borosilicate glass ampoules can only be used for ordinary antibiotic control injections. In contrast, neutral borosilicate glass ampoules are significantly superior to the former in terms of chemical stability and temperature abrupt change resistance. Taking chemical stability as an example, the water resistance of neutral borosilicate glass ampoule particle method can reach the first grade, while The particle method water resistance of low borosilicate glass ampoules is mostly first-class, but if you look at the amount of alkali precipitation from a microscopic point of view, it is much larger than neutral borosilicate glass. Therefore, it is used to hold strong acid, strong alkali drugs and high-grade For pharmaceuticals, there is a big difference in the chemical properties of these two glass ampoules.